carbonic anhydrase xii — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T36758	CAIX Inhibitor S4	S4	Carbonic Anhydrase
	CAIX Inhibitor S4 (S4) is an effective inhibitor of carbonic anhydrase IX/XII with a Ki of 7 nM and 2 nM, respectively. The Kis for CA II and CA I are 546 and 5600 nM.		Carbonic Anhydrase
T63305	Carbonic anhydrase inhibitor 6		Carbonic Anhydrase
	Carbonic anhydrase inhibitor 6 is a potent human carbonic anhydrase (hCA) inhibitor that inhibits hCA IX, hCA II, hCA XII, and hCA I. It is used in the study of diseases caused by abnormalities in carbonic anhydrase.		Carbonic Anhydrase
T77631	Enpp/Carbonic anhydrase-IN-2		Apoptosis , PDE , Carbonic Anhydrase
	Enpp/Carbonic anhydrase-IN-2 is a potent dual inhibitor of Enpp and carbonic anhydrase, inhibiting NPP1, NPP2, NPP3, CA-IX, CA-XII, with IC50 values of 1.13, 1.07, 0.74, 0.33, 0.68, respectively.Enpp/Carbonic anhydrase-I...		Apoptosis , PDE , Carbonic Anhydrase
T2017	U-104	NSC-213841,MST-104	Carbonic Anhydrase
	U-104 (NSC-213841) is an effective carbonic anhydrase (CA) inhibitor for CA IX( Ki=45.1 nM) and CA XII(Ki=4.5 nM).		Carbonic Anhydrase
T73177	HCAII-IN-9		Carbonic Anhydrase
	hCAII-IN-9 is a potent carbonic anhydrase inhibitor that inhibits hCA II, hCA IX, and hCA XII with IC50s of 1.18 μM and 0.17 μM , and 2.99 μM , respectively. hCAII-IN-9 is not blood-brain barrier permeable.		Carbonic Anhydrase
T61745	HCAI/II-IN-6		Carbonic Anhydrase
	hCAI/II-IN-6 is a selective and orally active inhibitor of human carbonic anhydrase (CA). hCAI/II-IN-6 inhibited hCA I, hCA II, hCA VII, and hCA XII with Ki values of 220, 4.9, 6.5, and ＞50,000 nM. hCAI/II-IN-6 showed an...		Carbonic Anhydrase
T63973	HCAXII-IN-3
	hCAXII-IN-3 (Compound 6o) is a selective inhibitor of human carbonic anhydrase XII (hCAXII) (Ki: 10.0 nM).
T63005	Carbonic anhydrase inhibitor 11
	Carbonic anhydrase inhibitor 11 (compound VI) is a potent, selective carbonic anhydrase inhibitor that acts on CA II (Ki: 40 nM), CA IX (Ki: 39 nM) and CA XII (Ki: 900 nM).
T62976	Carbonic anhydrase inhibitor 5
	Carbonic anhydrase inhibitor 5 is a potent and selective inhibitor of human carbonic anhydrase (hCA), acting on hCA II (IC50: 42.9 nM), hCA IX (IC50: 47.6 nM) and hCA XII (IC50: 6.7 nM).
T62666	Carbonic anhydrase inhibitor 7
	Carbonic anhydrase inhibitor 7 is a potent inhibitor of human carbonic anhydrase (hCA), acting on hCA IX (Ki: 6.5 nM), hCA II (Ki: 7.1 nM), hCA XII (Ki: 72.1 nM) and hCA I (Ki: 255.8 nM).
T62026	HCAIX-IN-11
	hCAIX-IN-11 (Compound 5d) is a selective carbonic anhydrase IX and XII inhibitor. hCAIX-IN-11 shows K i s of 32.7 and 623.5 nM for hCA IX and hCA XII, respectively.
T72164	Enpp/Carbonic anhydrase-IN-2
	Enpp/Carbonic anhydrase-IN-2 is a potent Enpp and carbonic anhydrase inhibitor with IC 50 s of 1.13, 1.07, 0.74, 0.33, 0.68 for NPP1, NPP2, NPP3, CA-IX, CA-XII respectively. Enpp/Carbonic anhydrase-IN-2 shows antiprolif...
T83137	ALP/Carbonic anhydrase-IN-1		Carbonic Anhydrase
	Compound 1e, also known as ALP/Carbonic anhydrase-IN-1, is a dual inhibitor targeting both carbonic anhydrase (CA) isozymes II, IX, and XII, as well as alkaline phosphatase (ALP). It exhibits inhibitory IC50 values of 0....		Carbonic Anhydrase
T78789	HCA XII-IN-6		Carbonic Anhydrase
	Compound 4d, known as hCA XII-IN-6, is a potent inhibitor of human carbonic anhydrase XII (hCA XII) with a Ki value of 84.2 nM and exhibits anti-proliferative effects, making it useful in cancer research [1].		Carbonic Anhydrase
T61842	Carbonic anhydrase inhibitor 14
	Carbonic anhydrase inhibitor 14 (Compound 8b) is a potent CA inhibitor, exhibiting K i values of 1203, 99.7, 9.4, and 27.7 nM against hCA I, hCA II, hCA IX, and hCA XII, respectively. Additionally, it effectively inhibit...
T63158	HCAIX-IN-10
	hCAIX-IN-10 (Compound 6i) is a selective inhibitor of carbonic anhydrase IX and XII, acting on hCA IX (Ki: 61.5 nM) and hCA XII (Ki: 586.8 nM). hCA IX and hCA XII are transmembrane isoforms of carbonic anhydrase that act...
T62755	HCAIX-IN-2
	HCAIX-IN-2 (compound 9d) is a selective inhibitor of carbonic anhydrase and acts on hCA IX (Ki: 24.6 nM) and hCA XII (Ki: 45.3 nM).
T62101	HCAXII-IN-2
	hCAXII-IN-2 (compound 5i) is a potent inhibitor of human carbonic anhydrase XII (hCA XII) (Ki: 84.2 nM) and hCA IX (Ki: 268.5 nM), with low activity against hCA I and hCA II.
T61164	HCAII-IN-3
	hCAII-IN-3 (Compound 16) is an inhibitor of human carbonic anhydrase (hCA). It exhibits high affinity for hCA I, hCA II, hCA IX, and hCA XII, with Ki values of 403.8 nM, 5.1 nM, 10.2 nM, and 5.2 nM, respectively. Notably...
T61263	HCA IX-IN-1
	hCA IX-IN-1 (Compound 6f) is a human carbonic anhydrase ( hCA ) inhibitor with K i values of 331.4, 28.4, 9.4 and 17.8 nM against hCA I, hCA II, hCA IX and hCA XII, respectively. hCA IX-IN-1 shows anticancer activity [1]...
T79411	HCAXII-IN-7		Carbonic Anhydrase
	hCAXII-IN-7 (compound 6e) functions as an inhibitor of human carbonic anhydrase XII (hCA XII) and possesses blood-brain barrier (BBB) permeability. Moreover, it promotes apoptosis in 786-0, SF-539, and HS 578 T cell line...		Carbonic Anhydrase
T63764	HCA XII/II/IX-IN-1
	hCA XII/II/IX-IN-1 is a potent inhibitor of human carbonic anhydrase (hCA) and is able to act on hCA I (IC50: 2.6 μM), hCA II (IC50: 0.004 μM), hCA IX (IC50: 0.005 μM) and hCA XII (IC50: 0.001 μM). hCA XII/II/IX -IN-1 ex...
T63631	HCAII-IN-2
	hCAII-IN-2 is a cytoplasmic human carbonic anhydrase (hCA) inhibitor that acts on hCA I (Ki: 261.4 nM), hCA II (Ki: 3.8 nM), hCA IX (Ki: 19.6 nM) and hCA XII (Ki: 45.2 nM).
T60602	HCAIX/XII-IN-5
	hCAIX/XII-IN-5 (Coumarin 9a) is an inhibitor of carbonic anhydrase (CA) that shows excellent hCA IX/XII selectivity with Kis of 93.3 and 85.7 nM over hCA I and hCA II, respectively. hCAIX/XII-IN-5 has anti-proliferative ...
T79748	HCAIX/XII-IN-7		Carbonic Anhydrase
	Compound 3e (hCAIX/XII-IN-7) is a potent inhibitor of human carbonic anhydrase (hCA) isozymes IX and XII, displaying inhibitory constants (Kis) of 503.7 nM for hCA IX and 59 nM for hCA XII, while also showing activity ag...		Carbonic Anhydrase
T72840	HCAIX/XII-IN-6
	hCAIX/XII-IN-6, an orally active carbonic anhydrase (CA) inhibitor, targets human CA isoforms hCA I, II, IV, IX, and XII with inhibition constants (K i) of 6697 nM, 2950 nM, 4093 nM, 4.1 nM, and 7.7 nM, respectively. Thi...
T74486	HCAIX-IN-17
	Compound 6f, also known as hCA IX-IN-1, is a human carbonic anhydrase (hCA) inhibitor that exhibits varying inhibitory effectiveness across different hCA isoforms, with K i values of 331.4 nM for hCA I, 28.4 nM for hCA I...
T79540	HCA/VEGFR-2-IN-1		Carbonic Anhydrase
	hCA/VEGFR-2-IN-1 (compound 13a) is a potent dual inhibitor targeting both Carbonic Anhydrase (CA) IX/XII and Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2). It exhibits Ki values of 4.7 nM for hCA XII and 8.3 nM...		Carbonic Anhydrase
T63400	HA2A/hCA XII modulator 1
	hA2A/hCA XII modulator 1 is a potent antagonist of the hA2A adenosine receptor (hA2AAR), a triazolopyrazine that acts on hA2AAR (Ki: 6.4 nM), hA1AR (Ki: 4.819 μM), and hA3AR (Ki>30 μM). hA2A/hCA XII modulator 1 Also a po...
T78705	COX-2-IN-30		COX
	COX-2-IN-30, a benzenesulfonamide derivative, is an orally active, dual inhibitor of cyclooxygenase-2 (COX-2; IC50 = 49 nM) and cyclooxygenase-1 (COX-1; IC50 = 10.4 μM), as well as 5-lipoxygenase (5-LOX; IC50 = 2.4 μM). ...		COX
T35876	Chlorthalidone Impurity G
	Chlorthalidone impurity G is a potential impurity found in commercial preparations of chlorthalidone that has moderate antihypertensive effects. Chlorthalidone is a thiazide-like diuretic that inhibits the Na+/Cl- cotran...

Compounds

CAIX Inhibitor S4

T36758

Synonym: S4

Target: Carbonic Anhydrase

Carbonic anhydrase inhibitor 6

T63305

Synonym:

Target: Carbonic Anhydrase

Enpp/Carbonic anhydrase-IN-2

T77631

Synonym:

Target: Apoptosis, PDE, Carbonic Anhydrase

U-104

T2017

Synonym: NSC-213841,MST-104

Target: Carbonic Anhydrase

hCAII-IN-9

T73177

Synonym:

Target: Carbonic Anhydrase

hCAI/II-IN-6

T61745

Synonym:

Target: Carbonic Anhydrase

Carbonic anhydrase inhibitor 11

T63005

Synonym:

Target:

Carbonic anhydrase inhibitor 5

T62976

Synonym:

Target:

Carbonic anhydrase inhibitor 7

Enpp/Carbonic anhydrase-IN-2

T72164

Synonym:

Target:

ALP/Carbonic anhydrase-IN-1

T83137

Synonym:

Target: Carbonic Anhydrase

hCA XII-IN-6

T78789

Synonym:

Target: Carbonic Anhydrase

Carbonic anhydrase inhibitor 14

Target: Carbonic Anhydrase

Target: Carbonic Anhydrase

Target: Carbonic Anhydrase

hA2A/hCA XII modulator 1

Chlorthalidone Impurity G

T35876

Synonym:

Target:

Cat No.	Product Name	Synonyms	Targets
T40611	(E)-Dehydrodiconiferyl alcohol
	(E)-Dehydrodiconiferyl alcohol is a potent dual inhibitor of hCA IX and hCA XII, effectively impeding the catalytic activity of both carbonic anhydrase isoforms. Additionally, (E)-Dehydrodiconiferyl alcohol exerts inhibi...

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-00694	Carbonic Anhydrase 12 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Carbonic Anhydrase 12 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.6 kDa and the accession number is O43570-1.
TMPY-00688	Carbonic Anhydrase 12 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Carbonic Anhydrase 12 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.8 kDa and the accession number is Q8CI85.
TMPK-00478	Carbonic Anhydrase 12 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	Carbonic anhydrases (CAs) are a family of enzymes involved in the pH regulation of metabolically active cells/tissues. Carbonic anhydrase XII (CA XII) is a key mediator of several signaling pathways that are involved in ...
TMPY-06944	Carbonic Anhydrase 12 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	Carbonic Anhydrase 12 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 33.45 kDa and the accession number is NP_001209.1...